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Robert M Hoffman Selected Research

Doxorubicin (Adriamycin)

1/2022ATR inhibition sensitizes liposarcoma to doxorubicin by increasing DNA damage.
12/2021Osteosarcoma Patient-derived Orthotopic Xenograft (PDOX) Models Used to Identify Novel and Effective Therapeutics: A Review.
10/2021The Combination of Cisplatinum and Doxorubicin Regressed Primary Osteosarcoma of the Breast in a PDOX Mouse Model.
7/2021Combination of CDK4/6 and mTOR Inhibitors Suppressed Doxorubicin-resistant Osteosarcoma in a Patient-derived Orthotopic Xenograft Mouse Model: A Translatable Strategy for Recalcitrant Disease.
1/2021An mTOR and VEGFR inhibitor combination arrests a doxorubicin resistant lung metastatic osteosarcoma in a PDOX mouse model.
7/2020Eribulin Regresses a Doxorubicin-resistant Dedifferentiated Liposarcoma in a Patient-derived Orthotopic Xenograft Mouse Model.
5/2020Recombinant Methioninase Combined With Tumor-targeting Salmonella typhimurium A1-R Induced Regression in a PDOX Mouse Model of Doxorubicin-resistant Dedifferentiated Liposarcoma.
1/2020The combination of oral-recombinant methioninase and azacitidine arrests a chemotherapy-resistant osteosarcoma patient-derived orthotopic xenograft mouse model.
10/2019Pioglitazone, an agonist of PPARĪ³, reverses doxorubicin-resistance in an osteosarcoma patient-derived orthotopic xenograft model by downregulating P-glycoprotein expression.
9/2019Eribulin Suppressed Cisplatinum- and Doxorubicin-resistant Recurrent Lung Metastatic Osteosarcoma in a Patient-derived Orthotopic Xenograft Mouse Model.
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Robert M Hoffman Research Topics

Disease

532Neoplasms (Cancer)
12/2022 - 03/2002
145Neoplasm Metastasis (Metastasis)
10/2022 - 04/2002
105Pancreatic Neoplasms (Pancreatic Cancer)
05/2022 - 04/2002
55Osteosarcoma (Osteogenic Sarcoma)
05/2022 - 03/2009
50Colonic Neoplasms (Colon Cancer)
10/2022 - 12/2004
30Prostatic Neoplasms (Prostate Cancer)
07/2022 - 07/2003
30Sarcoma (Soft Tissue Sarcoma)
11/2021 - 06/2007
28Breast Neoplasms (Breast Cancer)
12/2021 - 01/2002
27Melanoma (Melanoma, Malignant)
11/2020 - 07/2004
20Carcinoma (Carcinomatosis)
07/2022 - 07/2003
20Colorectal Neoplasms (Colorectal Cancer)
04/2022 - 02/2009
19Fibrosarcoma
01/2019 - 01/2003
16Lymphatic Metastasis
04/2022 - 01/2003
16Lung Neoplasms (Lung Cancer)
01/2022 - 06/2005
16Stomach Neoplasms (Stomach Cancer)
12/2021 - 02/2002
11Adenocarcinoma
07/2021 - 04/2002
10Liposarcoma
01/2022 - 01/2018
10Lymphoma (Lymphomas)
08/2019 - 04/2002
9Triple Negative Breast Neoplasms
09/2021 - 12/2014
9Ewing Sarcoma (Sarcoma, Ewing)
05/2019 - 07/2016
8Hepatocellular Carcinoma (Hepatoma)
03/2022 - 04/2016
8Adenocarcinoma of Lung
01/2022 - 06/2014
8Ovarian Neoplasms (Ovarian Cancer)
05/2020 - 01/2013
7Necrosis
09/2021 - 02/2011
6Lewis Lung Carcinoma
07/2021 - 01/2004
6Body Weight (Weight, Body)
05/2021 - 09/2013
6Glioma (Gliomas)
01/2019 - 09/2009
6Infections
01/2019 - 01/2006
5Inflammation (Inflammations)
10/2020 - 02/2010
5Rhabdomyosarcoma
02/2020 - 08/2006

Drug/Important Bio-Agent (IBA)

155Green Fluorescent ProteinsIBA
07/2022 - 01/2002
135Red Fluorescent ProteinIBA
02/2022 - 01/2003
94Proteins (Proteins, Gene)FDA Link
10/2022 - 04/2002
77Pharmaceutical PreparationsIBA
02/2022 - 01/2002
67L-methionine gamma-lyaseIBA
05/2022 - 08/2002
60Methionine (L-Methionine)FDA Link
05/2022 - 12/2003
54Doxorubicin (Adriamycin)FDA LinkGeneric
01/2022 - 03/2005
39GemcitabineFDA Link
01/2021 - 01/2003
26Fluorouracil (Carac)FDA LinkGeneric
05/2022 - 05/2002
22Histones (Histone)IBA
04/2022 - 06/2004
22NestinIBA
03/2017 - 01/2004
21Telomerase (Telomerase Reverse Transcriptase)IBA
01/2021 - 08/2002
19Temozolomide (Temodar)FDA LinkGeneric
12/2021 - 01/2013
17Indicators and Reagents (Reagents)IBA
11/2021 - 12/2011
16Carcinoembryonic AntigenIBA
12/2021 - 11/2008
15AntibodiesIBA
10/2022 - 01/2008
14EnzymesIBA
05/2022 - 08/2002
14Irinotecan (Camptosar)FDA LinkGeneric
05/2022 - 07/2003
14Paclitaxel (Taxol)FDA LinkGeneric
12/2021 - 07/2011
14IntegrinsIBA
01/2020 - 12/2011
13Coloring Agents (Dyes)IBA
12/2022 - 12/2013
12pazopanibFDA Link
09/2021 - 01/2015
12Docetaxel (Taxotere)FDA Link
04/2021 - 07/2012
11Small Interfering RNA (siRNA)IBA
01/2022 - 08/2006
11AntigensIBA
01/2021 - 06/2008
10Biomarkers (Surrogate Marker)IBA
12/2022 - 07/2003
10eribulinFDA Link
12/2021 - 01/2018
10Cyan Fluorescent ProteinIBA
01/2021 - 03/2009
9Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2021 - 02/2002
9Monoclonal AntibodiesIBA
09/2020 - 06/2008
9DNA (Deoxyribonucleic Acid)IBA
08/2019 - 08/2002
9Cisplatin (Platino)FDA LinkGeneric
04/2019 - 05/2002
8Fluorescent Dyes (Fluorescent Probes)IBA
12/2022 - 11/2011
8TrabectedinIBA
12/2021 - 09/2017
8palbociclibIBA
12/2021 - 07/2016
8Cytotoxins (Cytolysins)IBA
01/2021 - 01/2014
8Messenger RNA (mRNA)IBA
01/2020 - 02/2013
8LyasesIBA
01/2019 - 07/2004
8Amino AcidsFDA Link
01/2019 - 12/2003
7Cyclophosphamide (Cytoxan)FDA LinkGeneric
12/2021 - 05/2002
7Antineoplastic Agents (Antineoplastics)IBA
01/2021 - 09/2003
7Caffeine (No Doz)FDA LinkGeneric
02/2020 - 11/2013
7Biological ProductsIBA
01/2020 - 10/2003
7CollagenIBA
01/2019 - 01/2012
7Angiogenesis InhibitorsIBA
07/2011 - 03/2005
6Hematoxylin (Haematoxylon)IBA
07/2022 - 02/2013
6olaratumabIBA
12/2021 - 01/2019
6CytokinesIBA
10/2021 - 01/2013
6PlatinumIBA
07/2021 - 01/2016
6Phosphotransferases (Kinase)IBA
11/2016 - 03/2010
5Phenobarbital (Luminal)FDA Link
07/2022 - 02/2009
5Eosine Yellowish-(YS) (Eosin)IBA
07/2022 - 02/2013
5Carrier Proteins (Binding Protein)IBA
05/2022 - 11/2013
5Indocyanine Green (Cardio-Green)FDA LinkGeneric
03/2022 - 09/2020
5Sorafenib (BAY 43-9006)FDA Link
12/2021 - 01/2017
5regorafenibIBA
12/2021 - 01/2018
5Cell Adhesion MoleculesIBA
07/2021 - 04/2019
5Insulin (Novolin)FDA Link
05/2020 - 01/2016

Therapy/Procedure

187Therapeutics
07/2022 - 02/2002
83Drug Therapy (Chemotherapy)
02/2022 - 05/2002
28Transplantation
07/2022 - 11/2004
18Chinese Traditional Medicine (Traditional Chinese Medicine)
01/2022 - 07/2012
15Aftercare (After-Treatment)
05/2020 - 01/2013
12Lasers (Laser)
01/2022 - 06/2007
11Absorbable Gelatin Sponge
01/2021 - 05/2002
9Laparotomy
11/2020 - 06/2008
7Immunotherapy
04/2022 - 01/2017
6Intravenous Injections
01/2020 - 01/2012
6Neoadjuvant Therapy
09/2019 - 01/2014
5Injections
05/2020 - 10/2003